| Player | Runs | Balls | 4s | 6s | SR | Team | Opposition | Ground | Match Date | Scorecard | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| JC Buttler | 124 | 64 | 11 | 8 | 193.75 | Royals | v Sunrisers | Delhi | 2 May 2021 | T20 | |
| SV Samson | 119 | 63 | 12 | 7 | 188.88 | Royals | v Punjab Kings | Wankhede | 12 Apr 2021 | T20 | |
| D Padikkal | 101* | 52 | 11 | 6 | 194.23 | RCB | v Royals | Wankhede | 22 Apr 2021 | T20 | |
| RD Gaikwad | 101* | 60 | 9 | 5 | 168.33 | Super Kings | v Royals | Abu Dhabi | 2 Oct 2021 | T20 | |
| MA Agarwal | 99* | 58 | 8 | 4 | 170.68 | Punjab Kings | v Capitals | Ahmedabad | 2 May 2021 | T20 | |
| KL Rahul | 98* | 42 | 7 | 8 | 233.33 | Punjab Kings | v Super Kings | Dubai (DSC) | 7 Oct 2021 | T20 | |
| F du Plessis | 95* | 60 | 9 | 4 | 158.33 | Super Kings | v KKR | Wankhede | 21 Apr 2021 | T20 | |
| S Dhawan | 92 | 49 | 13 | 2 | 187.75 | Capitals | v Punjab Kings | Wankhede | 18 Apr 2021 | T20 | |
| KL Rahul | 91* | 57 | 7 | 5 | 159.64 | Punjab Kings | v RCB | Ahmedabad | 30 Apr 2021 | T20 | |
| KL Rahul | 91 | 50 | 7 | 5 | 182.00 | Punjab Kings | v Royals | Wankhede | 12 Apr 2021 | T20 | |
| RD Gaikwad | 88* | 58 | 9 | 4 | 151.72 | Super Kings | v Mumbai | Dubai (DSC) | 19 Sep 2021 | T20 | |
| KA Pollard | 87* | 34 | 6 | 8 | 255.88 | Mumbai | v Super Kings | Delhi | 1 May 2021 | T20 | |
| F du Plessis | 86 | 59 | 7 | 3 | 145.76 | Super Kings | v KKR | Dubai (DSC) | 15 Oct 2021 | T20 | |
| S Dhawan | 85 | 54 | 10 | 2 | 157.40 | Capitals | v Super Kings | Wankhede | 10 Apr 2021 | T20 | |
| Ishan Kishan | 84 | 32 | 11 | 4 | 262.50 | Mumbai | v Sunrisers | Abu Dhabi | 8 Oct 2021 | T20 | |
| PP Shaw | 82 | 41 | 11 | 3 | 200.00 | Capitals | v KKR | Ahmedabad | 29 Apr 2021 | T20 | |
| SV Samson | 82 | 57 | 7 | 3 | 143.85 | Royals | v Sunrisers | Dubai (DSC) | 27 Sep 2021 | T20 | |
| SA Yadav | 82 | 40 | 13 | 3 | 205.00 | Mumbai | v Sunrisers | Abu Dhabi | 8 Oct 2021 | T20 | |
| N Rana | 80 | 56 | 9 | 4 | 142.85 | KKR | v Sunrisers | Chennai | 11 Apr 2021 | T20 | |
| KS Bharat | 78* | 52 | 3 | 4 | 150.00 | RCB | v Capitals | Dubai (DSC) | 8 Oct 2021 | T20 | |
| GJ Maxwell | 78 | 49 | 9 | 3 | 159.18 | RCB | v KKR | Chennai | 18 Apr 2021 | T20 | |
| AB de Villiers | 76* | 34 | 9 | 3 | 223.52 | RCB | v KKR | Chennai | 18 Apr 2021 | T20 | |
| F du Plessis | 76 | 55 | 8 | 2 | 138.18 | Super Kings | v Punjab Kings | Dubai (DSC) | 7 Oct 2021 | T20 | |
| AB de Villiers | 75* | 42 | 3 | 5 | 178.57 | RCB | v Capitals | Ahmedabad | 27 Apr 2021 | T20 | |
| RD Gaikwad | 75 | 44 | 12 | 0 | 170.45 | Super Kings | v Sunrisers | Delhi | 28 Apr 2021 | T20 | |
| RA Tripathi | 74* | 42 | 8 | 3 | 176.19 | KKR | v Mumbai | Abu Dhabi | 23 Sep 2021 | T20 | |
| V Kohli | 72* | 47 | 6 | 3 | 153.19 | RCB | v Royals | Wankhede | 22 Apr 2021 | T20 | |
| AT Rayudu | 72* | 27 | 4 | 7 | 266.66 | Super Kings | v Mumbai | Delhi | 1 May 2021 | T20 | |
| PP Shaw | 72 | 38 | 9 | 3 | 189.47 | Capitals | v Super Kings | Wankhede | 10 Apr 2021 | T20 | |
| Q de Kock | 70* | 50 | 6 | 2 | 140.00 | Mumbai | v Royals | Delhi | 29 Apr 2021 | T20 | |
| SV Samson | 70* | 53 | 8 | 1 | 132.07 | Royals | v Capitals | Abu Dhabi | 25 Sep 2021 | T20 | |
| D Padikkal | 70 | 50 | 5 | 3 | 140.00 | RCB | v Super Kings | Sharjah | 24 Sep 2021 | T20 | |
| RD Gaikwad | 70 | 50 | 5 | 2 | 140.00 | Super Kings | v Capitals | Dubai (DSC) | 10 Oct 2021 | T20 | |
| S Dhawan | 69* | 47 | 6 | 2 | 146.80 | Capitals | v Punjab Kings | Ahmedabad | 2 May 2021 | T20 | |
| MK Pandey | 69* | 41 | 7 | 2 | 168.29 | Sunrisers | v Mumbai | Abu Dhabi | 8 Oct 2021 | T20 | |
| MA Agarwal | 69 | 36 | 7 | 4 | 191.66 | Punjab Kings | v Capitals | Wankhede | 18 Apr 2021 | T20 | |
| MA Agarwal | 67 | 43 | 7 | 2 | 155.81 | Punjab Kings | v Royals | Dubai (DSC) | 21 Sep 2021 | T20 | |
| VR Iyer | 67 | 49 | 9 | 1 | 136.73 | KKR | v Punjab Kings | Dubai (DSC) | 1 Oct 2021 | T20 | |
| KL Rahul | 67 | 55 | 4 | 2 | 121.81 | Punjab Kings | v KKR | Dubai (DSC) | 1 Oct 2021 | T20 | |
| PJ Cummins | 66* | 34 | 4 | 6 | 194.11 | KKR | v Super Kings | Wankhede | 21 Apr 2021 | T20 | |
| KS Williamson | 66* | 51 | 8 | 0 | 129.41 | Sunrisers | v Capitals | Chennai | 25 Apr 2021 | T20 | |
| S Dube | 64* | 42 | 4 | 4 | 152.38 | Royals | v Super Kings | Abu Dhabi | 2 Oct 2021 | T20 | |
| DJ Hooda | 64 | 28 | 4 | 6 | 228.57 | Punjab Kings | v Royals | Wankhede | 12 Apr 2021 | T20 | |
| RD Gaikwad | 64 | 42 | 6 | 4 | 152.38 | Super Kings | v KKR | Wankhede | 21 Apr 2021 | T20 | |
| JM Bairstow | 63* | 56 | 3 | 3 | 112.50 | Sunrisers | v Punjab Kings | Chennai | 21 Apr 2021 | T20 | |
| RG Sharma | 63 | 52 | 5 | 2 | 121.15 | Mumbai | v Punjab Kings | Chennai | 23 Apr 2021 | T20 | |
| RV Uthappa | 63 | 44 | 7 | 2 | 143.18 | Super Kings | v Capitals | Dubai (DSC) | 10 Oct 2021 | T20 | |
| RA Jadeja | 62* | 28 | 4 | 5 | 221.42 | Super Kings | v RCB | Wankhede | 25 Apr 2021 | T20 | |
| DA Miller | 62 | 43 | 7 | 2 | 144.18 | Royals | v Capitals | Wankhede | 15 Apr 2021 | T20 | |
| MK Pandey | 61* | 44 | 2 | 3 | 138.63 | Sunrisers | v KKR | Chennai | 11 Apr 2021 | T20 |
| Records includes the following current or recent matches: |
|
Chennai Super Kings v Kolkata Knight Riders at Dubai (DSC), Indian Premier League final, Oct 15, 2021
[Twenty20] |
|
Delhi Capitals v Kolkata Knight Riders at Sharjah, Indian Premier League 2nd qualifying final, Oct 13, 2021
[Twenty20] |
|
Royal Challengers Bangalore v Kolkata Knight Riders at Sharjah, Indian Premier League elimination final, Oct 11, 2021
[Twenty20] |
